Total synthesis of ibogaine,epiibogaine and their analogues |
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Authors: | Goutam Kumar Jana Surajit Sinha |
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Institution: | Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India |
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Abstract: | Efficient total synthesis of ibogaine, epiibogaine and their analogues has been described. An intramolecular reductive-Heck type cyclization was used for the construction of seven-membered indoloazepine ring to access iboga-skeleton. Larock’s heteroannulation reaction was employed for the creation of suitably substituted indole and Diels–Alder reaction was employed for the construction of the isoquinuclidine ring present in iboga alkaloids. |
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Keywords: | Iboga alkaloids Reductive-Heck coupling Indoloazepine ring Isoquinuclidine |
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