Efficient use of a surfactant for copper-catalyzed coupling reaction of arylboronic acids with imidazoles in water |
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Authors: | Kiyofumi Inamoto Kanako Nozawa Jun Kadokawa Yoshinori Kondo |
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Institution: | Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan |
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Abstract: | Copper-catalyzed oxidative coupling of arylboronic acids with imidazoles in water was realized by using an amphiphilic surfactant. By choosing an appropriate surfactant, reactions of a variety of arylboronic acids proceeded smoothly under mild and base-free conditions, providing an efficient, practical, and greener method for the synthesis of N-arylimidazoles. |
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