Catalyst-free synthesis of N-rich heterocycles via multi-component reactions |
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Authors: | Zeinab Noroozi Tisseh Minoo Dabiri Mohsen Nobahar Ali Abolhasani Soorki Ayoob Bazgir |
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Institution: | 1. Department of Chemistry, Shahid Beheshti University G.C., Tehran 1983963113, Iran;2. Research Institute of Applied Sciences, Academic Center for Education, Culture and Research, Shahid Beheshti University, Tehran, Iran |
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Abstract: | Efficient and straightforward methods for the synthesis of 5-substituted 1H-tetrazoles via multi-component reaction of α-dicarbonyl compounds, 2,3-diaminomaleonitrile and sodium azide without any catalyst has been reported. These general protocols provide a wide variety of N-rich heterocyclic compounds (1H-tetrazole-5-yl) pyrazines and di(1H-tetrazole-5-yl) pyrazines, in good to excellent yields. |
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