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Palladium-catalyzed direct arylation using free NH2 substituted thiophene derivatives with inhibition of amination type reaction |
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| Authors: | Fazia Derridj Karima Si Larbi Julien Roger Safia Djebbar Henri Doucet |
| Institution: | 1. Laboratoire d''hydrométallurgie et chimie inorganique moléculaire, Faculté de Chimie, U.S.T.H.B. Bab-Ezzouar, Algeria;2. Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes, France |
| Abstract: | The palladium-catalyzed direct arylation at C2 or C5 of free NH2 substituted thiophene derivatives was found to proceed in moderate to high yields using a variety of aryl halides. The choice of potassium acetate as the base was found to be crucial to inhibit the amination reaction and to promote the direct arylation. |
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