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A new and facile access to the 2-(indol-3-yl)-3-nitriloquinolines based on Friedländer annulations |
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| Authors: | Morteza Shiri Mohammad Ali Zolfigol Mahtab Pirveysian Roya Ayazi-Nasrabadi Hendrik G Kruger Tricia Naicker Iraj Mohammadpoor-Baltork |
| Institution: | 1. Department of Chemistry, Faculty of Science, Alzahra University, Vanak, Tehran 1993893973, Iran;2. Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran;3. School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa;4. Department of Chemistry, Catalysis Division, University of Isfahan, Isfahan 81746-73441, Iran |
| Abstract: | Preparation of 2-(indol-3-yl)-3-nitriloquinolines via Friedländer quinoline synthesis using 3-cyanoacetylindoles possessing an α-methylene group and ortho-amino arylketones have been described. This reaction took place in PEG-400 as a green solvent and it is catalyzed with polyphosphoric acid (PPA) to give novel types of quinolines containing both indoles and cyano functions in one step under thermal and microwave conditions. |
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