Synthesis of CF3-containing tetrapeptide surrogates via Ugi reaction/dipolar cycloaddition sequence |
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| Authors: | Daria V. Vorobyeva Nadezhda V. Sokolova Valentine G. Nenajdenko Alexander S. Peregudov Sergey N. Osipov |
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| Affiliation: | 1. A.N. Nesmeyanov Institute of Organoelement compounds, Russian Academy of Sciences, Vavilov Str. 28, Moscow 119991, Russia;2. Moscow State University, Department of Chemistry, Leninskie Gory 1, Moscow 119992, Russia |
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| Abstract: | A convenient synthetic pathway to novel functionalized tetrapeptides containing the 1,2,3-triazole moiety is described. The target molecules were obtained by the reaction of fluorinated α-amino acids or α-aminophosphonates with azidopeptides via Cu(I)-catalyzed Huisgen cycloaddition reaction (click chemistry). The synthesized tetrapeptides may find important applications in biomedical chemistry as potential drugs. |
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