A one-pot three-component reaction for the preparation of highly functionalized tryptamines |
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| Authors: | Se Jeong Yeo Yongxiang Liu Xiang Wang |
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| Institution: | Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA |
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| Abstract: | We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2-methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is described. |
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