A simple metal-free synthesis of 2-substituted pyridine-4,5-dicarboxylates and their N-oxides |
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| Authors: | Jure Bezenšek Benjamin Prek Uroš Grošelj Marta Kasunič Jurij Svete Branko Stanovnik |
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| Affiliation: | Faculty of Chemistry and Chemical Technology, University of Ljubljana, A?ker?eva 5, 1000 Ljubljana, Slovenia |
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| Abstract: | Herein a simple, metal-free synthesis of 2-alkyl-, 2-cycloalkyl-, 2-aryl-, and 2-heteroaryl-substituted pyridine 3,4-dicarboxylates and their N-oxides from the corresponding methyl ketones in good to excellent yield, demonstrated with 22 examples in each case, is described. The method complements the current coupling reactions of 2-heterocyclic organometallic reagents. |
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