An efficient synthesis of 2H-indazoles via reductive cyclization of 2-nitrobenzylamines induced by low-valent titanium reagent |
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| Authors: | Fang Sun Xian Feng Xuan Zhao Zhi-Bin Huang Da-Qing Shi |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China |
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| Abstract: | An efficient and improved synthesis of 2H-indazoles via reductive cyclization of 2-nitrobenzylamines induced by low-valent titanium reagent (TiCl4/Zn) is described. In this reaction triethylamine (TEA) was used to control the pH value. This method has the advantages of easily accessible starting materials, convenient manipulation, higher yield, shorter reaction time, and wider substrate scope. |
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