Stereoselective synthesis of analogs of the macrolactone of isomigrastatin |
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| Authors: | Luiz C. Dias Gustavo C. Monteiro Giovanni W. Amarante Leila S. Conegero Fernanda G. Finelli |
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| Affiliation: | University of Campinas, Institute of Chemistry, Organic Chemistry Department, PO Box 6154, 13083-970 Campinas, SP, Brazil |
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| Abstract: | An approach for the highly stereoselective synthesis of analogs of the macrolactone of isomigrastatin is described. Our optimized strategy is based on a very efficient lactone opening, a Wittig olefination reaction and a ring closing metathesis. The syntheses were accomplished in 10–11 steps and good overall yields. |
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