Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle |
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| Authors: | Min Zhang Xiuling Cui Xiaopei Chen Lianhui Wang Jingya Li Yusheng Wu Lifen Hou Yangjie Wu |
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| Affiliation: | 1. Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Department of Chemistry, Zhengzhou University, Daxue Road 75#, Zhengzhou 450052, PR China;2. Tetranov Biopharm, Inc. Zhengzhou 450052, PR China |
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| Abstract: | Sphos (2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl) adduct of cyclopalladated ferrocenylimine (IIe) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated. |
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