Stereocontrolled synthesis of (S)-9-cis-4-oxo-13,14-dihydroretinoic acid |
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| Authors: | Marta Domínguez Susana Álvarez Rosana Álvarez Ángel R. de Lera |
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| Affiliation: | Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain |
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| Abstract: | (S)-9-cis-4-Oxo-13,14-dihydroretinoic acid (S)-1, a new major endogenous vitamin A metabolite that activates retinoic acid receptor signaling both in vitro and in vivo, has been synthesized stereoselectively by Horner–Wadsworth–Emmons condensation and Stille cross-coupling as bond forming reactions. |
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