Efficient synthesis of spiroisoxazoline oxindoles |
| |
| Authors: | Carlos J.A. Ribeiro S. Praveen Kumar Rui Moreira Maria M.M. Santos |
| |
| Affiliation: | Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal |
| |
| Abstract: | The synthesis of spiroisoxazoline oxindoles containing ester groups at position 4′ and aromatic or ester groups at position 3′ of the isoxazoline ring is reported. The compounds were synthesized in yields up to 94% by 1,3-dipolar cycloaddition of 3-methylene indolin-2-ones and chlorooximes in the presence of triethylamine or zinc. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
