Palladium-catalyzed one-pot synthesis of polysubstituted furans from alkynoates and 2-yn-1-ols |
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Authors: | Huawen Huang Huanfeng Jiang Hua Cao Jinwu Zhao Dabin Shi |
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Institution: | School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People’s Republic of China |
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Abstract: | Easily accessible propargyl vinyl ethers are found to be acyclic precursors to construct furan derivatives. According to the reactive behavior of the substrates and the regulation of reaction conditions, three synthetic routes to polysubstituted furans via palladium-catalyzed reactions of propargyl vinyl ethers in situ-prepared from alkynoates and 2-yn-1-ols are presented herein. These methods could have potential application in synthetic and pharmaceutical chemistry for its facilitation and accessible starting materials. |
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