Efficient palladium-catalyzed amination of aryl chlorides using di(dicyclohexylamino)phenylphosphine as a PN2 ligand |
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Authors: | Bo Ram Kim Su-Dong Cho Eun Jung Kim In-Hye Lee Gi Hyeon Sung Jeum-Jong Kim Sang-Gyeong Lee Yong-Jin Yoon |
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Institution: | 1. Department of Chemistry, Research Institute of Natural Science, Graduate School for Materials and Nanochemistry, Gyeongsang National University, Jinju 660-701, Republic of Korea;2. Advanced Solar Technology Research Department, ETRI, Daejeon 305-700, Republic of Korea |
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Abstract: | The palladium-catalyzed amination of a variety of aryl chlorides has been accomplished by using di(dicyclohexylamino)phenylphosphine (1) as a bulky electron-rich monoaryl phosphine ligand. The optimized condition for the palladium-catalyzed amination of aryl chloride is the followings: aniline (3.0 mmol, 1.0 equiv), chlorobenzene (3.15 mmol, 1.05 equiv), ligand 1 (1 mol %, 0.03 mmol), KOtBu (4.5 mmol, 1.5 equiv), Pd2(dba)3 (1 mol %, 0.03 mmol), and toluene as solvent at reflux temperature. We report on couplings of various amines or chloroamines with chlorobenzenes and heteroaryl chloride. |
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