Synthesis of the novel pyrimido[1,6-a]pyrimidine and imidazo[1,2-c]pyrimidine derivatives based on heterocyclic ketene aminals |
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Authors: | Abdolali Alizadeh Javad Mokhtari Mehdi Ahmadi |
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Institution: | Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran |
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Abstract: | A concise and efficient route for the synthesis of pyrimido1,6-a]pyrimidines and imidazo1,2-c]pyrimidines by simply refluxing a reaction mixture of different heterocyclic ketene aminals and N,N′-bis(arylmethylidene)arylmethane was developed. This protocol provides an alternative method for application in combinatorial and parallel synthesis in drug discovery. |
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