Synthesis of two osteoclast-forming suppressors,demethylincisterol A3 and chaxine A

The synthesis of two potent osteoclast-forming suppressing agents isolated from the Chinese mushroom Agrocybe chaxingu, demethylincisterol A₃ and chaxine A, was accomplished using ergocalciferol as the starting material. Our methodology for the synthesis of demethylincisterol A₃ and chaxine A featured the construction of a butenolide moiety by the intramolecular Horner–Wadsworth–Emmons reaction under Masamune–Roush conditions. This is the first reported synthesis of chaxine A.