Influence of chiral thiols on the diastereoselective synthesis of γ-lactams from cyclic anhydrides |
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| Authors: | Ashkaan Younai James C Fettinger Jared T Shaw |
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| Institution: | Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616, USA |
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| Abstract: | The synthesis of γ-lactams from both four-component and imine-anhydride reactions is reported. The synthesis of 2-phenylcyclohexanethiol is described and this compound was evaluated along with an additional seven chiral thiols. A range of selectivity and yields was observed and comparisons to established reactions are made in order to account for the observed reactivity. |
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