Active methylene compounds in a very effective approach to 3-substituted isobenzofuranones through tandem aldol/lactonization reactions |
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Authors: | Antonia Di Mola Gianluca Croce Vijaykumar More Paolo De Caprariis Rosanna Filosa Antonio Massa |
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Institution: | 1. Dipartimento di Chimica e Biologia, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy;2. Dipartimento di Scienze Farmaceutiche e Biomediche, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy;3. DISIT-Universita'' del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy |
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Abstract: | In this article we describe a new accessible methodology for the synthesis of isobenzofuran-1(3H)-ones. In this process we exploited an effective, economic, useful and environmentally benign K2CO3 catalyzed, solvent-free one-pot tandem aldol-lactonization reaction between active methylene compounds and methyl 2-carboxy benzaldehyde. A particularly simple work-up and purification procedure are additional advantages addressed to a general green chemistry approach to this important class of heterocyclic compounds. |
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