Phosphonium salt-catalysed synthesis of nitriles from in situ activated oximes |
| |
Authors: | Ross M Denton Jie An Petra Lindovska William Lewis |
| |
Institution: | School of Chemistry University of Nottingham, University Park, Nottingham NG7 2RD, UK |
| |
Abstract: | A metal-free catalytic method for the conversion of aromatic and aliphatic aldoximes to nitriles at room temperature using oxalyl chloride (1.2 equiv) in combination with 5 mol % of triphenylphosphine oxide is reported. Of the many potential pathways leading from oxime to nitrile a manifold involving chlorophosphonium salt-catalysed decomposition of oxime chlorooxalates formed in situ is shown to be operative. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |