A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design,synthesis and biophysical evaluation |
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Authors: | Dougal J Ritson John E Moses |
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Institution: | School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK |
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Abstract: | A library of hybrid oxazole–triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design of these ligands was based upon combining features of our first generation of G-quadruplex bis-triazole ligands and the natural product telomestatin. The syntheses and biophysical studies of these ligands are described. |
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