Three new diterpenes from Jatropha curcas |
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Authors: | Jie-Qing Liu Yuan-Feng Yang Cui-Fang Wang Yan Li Ming-Hua Qiu |
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Institution: | State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Lanhei Road, 132, Kunming 650204, Yunnan, PR China |
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Abstract: | Jatrophalactone (1) and jatrophalone (2), together with jatrophadiketone (3), a 6/6/6 tricyclic diterpene transformed from rhamnofolane skeleton, have been isolated from the methanolic extract of Jatropha curcas. The structures were established on the basis of extensive spectroscopic methods and further confirmed by X-ray crystallographic analysis. The cytotoxicity against selected cell lines was evaluated. Among them, compound 1 displayed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines with IC50 values of 8.5, 20.6, 19.7, 20.1, and 19.2 μM, respectively. The possible biosynthetic pathways for 1 and 3 are proposed. |
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