Access to 2-alkyl chromanones via a conjugate addition approach |
| |
Authors: | Louise A Stubbing Freda F Li Daniel P Furkert Vittorio E Caprio Margaret A Brimble |
| |
Institution: | School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, New Zealand |
| |
Abstract: | The introduction of alkyl substituents at C-2 of chromanones via conjugate addition of silyl enol ethers to a variety of chromenones is reported. In most cases racemic 2-alkyl chromanones were obtained in good yield in the presence of TMSOTf. The copper(II)-promoted conjugate addition of silyl enol ethers to chromenones was also carried out, albeit in low yields and no selectivity. Reliable syntheses of the chromenones via acylation of the corresponding β-diketo-compounds are also described. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |