Enantioselective hydrogenation of (Z)- and (E)-β-arylenamides catalyzed by rhodium complexes of monodentate chiral spiro phosphorous ligands: a new access to chiral β-arylisopropylamines |
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Authors: | Shou-Fei Zhu Tao Liu Shuang Yang Song Song Qi-Lin Zhou |
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Institution: | State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China |
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Abstract: | A highly enantioselective rhodium-catalyzed hydrogenation of both (Z)- and (E)-β-arylenamides was developed by using monodentate chiral spiro phosphite and phosphine ligands, respectively. The hydrogenation reaction provides an efficient access to optically active β-arylisopropylamines, important building blocks for the synthesis of biologically active compounds. |
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