CuCl-catalyzed stereoselective conjugate addition of Grignard reagents to 2,3-allenoates |
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| Authors: | Jian He Zhan Lu Guobi Chai Chunling Fu Shengming Ma |
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| Institution: | Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, 310027 Hangzhou, Zhejiang, PR China |
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| Abstract: | CuCl was found to be an efficient catalyst for the conjugate addition of 2,3-allenoates with Grignard reagents to synthesize poly-substituted β,γ-unsaturated alkenoates with high stereoselectivity in good to excellent yields. Primary, secondary, and tertiary alkyl, vinyl or phenyl Grignard reagents may all be used. |
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