Total synthesis of sapinofuranone A from d-ribose |
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Authors: | Lingaiah Nagarapu Shuklachary Karnakanti Rajashaker Bantu |
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Institution: | Organic Chemistry Division-II, Indian Institute of Chemical Technology (CSIR), Tarnaka, Hyderabad 500607, India |
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Abstract: | The total synthesis of sapinofuranone A has been achieved starting from naturally occurring carbohydrate d-ribose via a short and high yielding route. The key transformations include Wittig olefination, Ohira–Bestmann reaction, Sonogashira coupling. Finally acetonide deprotection and subsequent lactonization using catalytic amount of hydrochloric acid completed the total synthesis of sapinofuranone A. |
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