Synthesis of 2,5-disubstituted-3-cyanoindoles |
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| Authors: | Mark A Bobko Karen A Evans Arun C Kaura Leanna E Shuster Dai-Shi Su |
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| Institution: | GlaxoSmithKline, Cancer Research, 1250 South Collegeville Road, Collegeville, PA 19426, USA |
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| Abstract: | An efficient synthesis of 2,5-disubstituted-3-cyanoindoles is described. This approach utilizes a highly selective iodination together with the modified Madelung reaction to generate an intermediate which can be readily transformed to more fully elaborated 2,5-disubstituted-3-cyanoindole templates that were previously difficult to access. Detailed examples and utility of this approach are presented herein. |
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