Aromatic garlands,as new foldamers,to mimic protein secondary structure |
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Authors: | Anne Sophie Voisin-Chiret Grégory Burzicki Serge Perato Marcella De Giorgi Carlo Franchini Jana Sopková-de Oliveira Santos Sylvain Rault |
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Institution: | 1. Université de Caen Basse-Normandie, Centre d’Etudes et de Recherche sur le Médicament de Normandie (UPRES EA 4258-FR CNRS 3038 INC3M), UFR des Sciences Pharmaceutiques, F-14032 Caen Cedex, France;2. Université de Bari, Département de Chimie médicinale, I-70125 Bari, Italy |
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Abstract: | Proteins modulate the majority of all biological functions and are composed of highly organized secondary structural elements such as helices, turns, and sheets. Many of these functions are affected by a small number of key structural element, protein–protein interactions. Their mimicry by peptide and non-peptide scaffolds has become a major focus of contemporary research. This paper examines oligomeric system as new foldamers, which either reproduce the local topography of the helix, or project appropriately functionality in a similar manner to residues of an alpha-helix. |
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