An efficient synthesis of tert-butyl ethers/esters of alcohols/amino acids using methyl tert-butyl ether |
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Authors: | N Mallesha S Prahlada Rao R Suhas D Channe Gowda |
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Institution: | 1. Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India;2. R&D Centre, CJEX Biochem, 7&8, 2nd cross, Muniswamappa layout, Hosur Road, Bommanahalli, Bangalore 560 068, India |
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Abstract: | A facile synthesis of a wide variety of tert-butyl ethers and tert-butyl ester derivatives under mild conditions is described. Alcohols etherified with tert-butyl methyl ether as tert-butyl source and solvent, in the presence of sulfuric acid. Many amino acid tert-butyl esters have been synthesized by this procedure. The reaction is simple, inexpensive, easily scaled up, and proceeds without observable racemization. A green method was developed for the deprotection of this group using Amberlite resin IR 120-H as catalyst. |
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