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EDTA and DTPA modified ligands as sequestering agents for uranyl decorporation |
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| Authors: | Antoine Leydier Yi Lin Guilhem Arrachart Raphaël Turgis Delphine Lecerclé Alain Favre-Reguillon Frédéric Taran Marc Lemaire Stéphane Pellet-Rostaing |
| Institution: | 1. ICBMS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, CNRS, UMR 5246, Université de Lyon, INSA, CPE, Laboratoire de Catalyse et Synthèse Organique, 43 Bd du 11 novembre 1918, Villeurbann F-69622, France;2. ICSM, Institut de Chimie Séparative de Marcoule, CNRS/CEA/UM2/ENSCM, UMR 5257, Université Montpellier 2, Laboratoire de Tri ionique par des Systèmes Moléculaire auto-assemblés, site de Marcoule, 30207 Bagnols sur Cèze, France;3. Service de Chimie Bio-organique et de Marquage, iBiTec-S, CEA-Saclay 91191 Gif sur Yvette, France |
| Abstract: | Synthesis of modified EDTA and DTPA ligands and determination of their binding affinities for the uranyl cation are described.Thanks to a screening method, based on a chromophoric complex displacement procedure, chelating properties were studied in aqueous media under various pH conditions for evaluation of their in vivo uranyl-removal efficacy. Each ligand showed a more or less pronounced affinity for uranium. Specific ligands based on EDTA or DTPA analogues containing sulfocatecholamide (CAMS) were found to exhibit a significant affinity towards uranyl ion in acidic, neutral or basic conditions. |
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