Assessing the folding propensity of aliphatic units within helical aromatic oligoamide foldamers |
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Authors: | Nicolas Delsuc Legiso Poniman Jean-Michel Léger Ivan Huc |
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Institution: | 1. Univ. Bordeaux—CNRS—IPB UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France;2. Univ. Bordeaux—CNRS FRE 3396, 146 rue Léo Saignat, 33076 Bordeaux, France |
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Abstract: | Great attention is devoted to hybrid foldamers composed of more than one type of monomers. The folding of such hybrids requires units that may possess very different structures to be compatible. A method to assess this compatibility consists in studying the behavior of a monomer of one type within a sequence of another type of monomer. We have prepared and investigated the structure of flexible aliphatic monomers in the context of the rigid helices of quinoline-carboxamides. NMR and X-ray crystallography show that the rigid helical backbones may impart defined conformation into otherwise flexible units and that compatible folding modes exist between very different monomers. |
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