Fulvynes,antimicrobial polyoxygenated acetylenes from the Mediterranean sponge Haliclona fulva |
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| Authors: | Genoveffa Nuzzo Maria Letizia Ciavatta Guido Villani Emiliano Manzo Anna Zanfardino Mario Varcamonti Margherita Gavagnin |
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| Affiliation: | 1. Consiglio Nazionale delle Ricerche, Istituto di Chimica Biomolecolare, Via Campi Flegrei, 34-80078-I Napoli, Italy;2. Dip. di Biologia Strutturale e Funzionale, Università Federico II di Napoli, Via Cinthia, 80126 Napoli, Italy |
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| Abstract: | Nine linear polyoxygenated acetylenes, fulvynes A–I (1–9), exhibiting the uncommon 2-yne carboxylic acid functionality, have been isolated from the butanolic extract of the Mediterranean sponge Haliclona fulva. Their structures possess a long alkyl chain with several oxygenated carbons, and were established by detailed spectroscopic analysis. All fulvynes were found to be active against a chloramphenicol-resistant strain of Bacillus subtilis. |
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