Transformation of a hydroxyl into an acyl group on α-pyrone ring: a novel route to 3,4-diacylcoumarins |
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| Authors: | Antigoni Kotali Despina A Nasiopoulou Philip A Harris Madeleine Helliwell John A Joule |
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| Institution: | 1. Laboratory of Organic Chemistry, Department of Chemical Engineering, University of Thessaloniki, 54124, Greece;2. GlaxoSmithKline, 1250 South Collegeville Road, P.O. Box 5089, Collegeville, PA 19426-0989, USA;3. The School of Chemistry, The University of Manchester, Manchester M13 9PL, UK |
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| Abstract: | The transformation of a hydroxyl into an acyl group, a transformation which has been extensively investigated on the benzene nucleus of several substrates, is now applied successfully for the first time to a heterocyclic ring and specifically to the pyrone ring of coumarin to yield novel 3,4-diacylcoumarins in good yields. The reaction involves formation of a new C–C bond. |
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