The synthesis of phosphine oxide-linked bis(oxazoline) ligands and their application in asymmetric allylic alkylation |
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Authors: | Yu Jin Da-Ming Du |
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Institution: | School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, China |
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Abstract: | The phosphine oxide-linked bis(oxazoline) ligands were designed and synthesized in two ways. One is the coupling of Grignard reagent derived from 2-(2-bromophenyl)oxazoline with phenylphosphonic dichloride, another route is the condensation of bis(2-formylphenyl)(phenyl)phosphine oxide with chiral amino alcohols followed by NBS oxidation. These new bis(oxazoline) ligands were applied in Pd-catalyzed asymmetric allylic alkylation reactions and good yields and enantioselectivities were obtained with diphenyl substituted ligand (up to 95% ee). |
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