| 核磁共振的差谱在天然产物研究中的应用（Ⅰ） |
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| 引用本文： | 薛松,胡皆汉,张卫,袁权. 核磁共振的差谱在天然产物研究中的应用（Ⅰ）[J]. 波谱学杂志, 2003, 20(4): 379-385 |
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| 作者姓名： | 薛松 胡皆汉 张卫 袁权 |
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| 作者单位： | 中国科学院大连化学物理研究所，辽宁大连 116023 |
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| 基金项目： | 国家“8 63”高科技研究发展计划项目 (No.2 0 0 1AA62 0 40 4) |
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| 摘 要： | 提出应用核磁共振差谱研究天然产物混合物的方法. 在对黄海繁茂膜海绵天然产物的研究中，通过柱分离的溶剂强度连续变化，获得连续洗脱物，对这几个连续洗脱物的核磁共振谱图进行比较得出差谱，实现核磁共振谱峰的分类、归属，从而解析出各个化合物. 在此过程中也可以获得被分离物与溶剂强度之间的关系.
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| 关 键 词： | 核磁共振 差谱 天然产物 邻苯二甲酸二酯类 繁茂膜海绵 |
| 文章编号： | 1000-4556(2003)04-0379-07 |
| 收稿时间： | 2003-04-28 |
| 修稿时间： | 2003-04-28 |
APPLICATION OF NMR DIFFERENCE SPECTRA ON NATURAL PRODUCT MIXTURES |
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| XUE Song,HU Jie han,ZHANG Wei+,YUAN Quan. APPLICATION OF NMR DIFFERENCE SPECTRA ON NATURAL PRODUCT MIXTURES[J]. Chinese Journal of Magnetic Resonance, 2003, 20(4): 379-385 |
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| Authors: | XUE Song HU Jie han ZHANG Wei+ YUAN Quan |
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| Affiliation: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China |
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| Abstract: | We report a methodology that allows identification of natural mixtures, using difference spectra of several NMR spectra. During the study on natural products from marine sponge Hymeniacidon perleve we obtained the consecutive elutates by column chromatography with the eluent(the value of ε0 from 0.2～0.3) then NMR and GC-MS were used to determine the composition of the elutates. By comparing thespectra of the elutates we could classify the peaks into several groups and assign the partial peaks to identify the compounds. In the process we obtained the relationship between elutates and ε0. |
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| Keywords: | NMR natural product mixtures phthalates marine sponge Hymeniacidon perleve |
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