Conformational Polymorphism in Racemic 2,4-Di-<Emphasis Type="Italic">o</Emphasis>-Benzoyl-6-<Emphasis Type="Italic">o</Emphasis>-Tosyl <Emphasis Type="Italic">myo</Emphasis>-Inositol 1,3,5-Orthoacetate |
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Authors: | K Manoj R G Gonnade M M Bhadbhade M S Shashidhar |
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Institution: | (1) Department of Pharmaceutical Technology, School of Pharmacy, University of Thessaloniki, Thessaloniki, 54124, Greece;(2) Institute of Pharmacy, University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria;(3) Solvias AG, Klybeckstrasse 191, 4002 Basel, Switzerland |
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Abstract: | The title compound, C29H26O10S, yields two conformational polymorphs concomitantly from dichloromethane-methanol mixture; the major polymorph grows as
plates (Form I, monoclinic, P21/n) and the minor polymorph grows as needles (Form II, triclinic, P-1). The two forms differ mainly in orientation of the tosyl group. In Form I, sulfonyl oxygen of the tosyl group makes intermolecular
C −H…O interactions, whereas the same group in Form II is involved in an intramolecular short dipolar S=O…C=O (sulfonyl-carbonyl)
contact. The molecular organization and the influence of various weak non-covalent interactions that stabilize these conformers
in the crystal lattices are discussed. |
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Keywords: | |
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