Enantioselective total synthesis of (-)-clavosolide B |
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Authors: | Son Jung Beom Hwang Min-ho Lee Wonsun Lee Duck-Hyung |
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Affiliation: | Department of Chemistry, Sogang University, Shinsoo-dong 1, Mapo-gu, Seoul 121-742, Korea. |
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Abstract: | Enantioselective synthesis of 2, a revised structure for (-)-clavosolide B, was accomplished by a convergent approach, where syn-selective aldol, hydroxy-directed cyclopropanation, Mitsunobu inversion, Schmidt-type glycosylation, and macrolactonization reactions were utilized as key reactions. Comparison of 1H and 13C NMR spectra and optical rotation measurement confirmed the relative and absolute stereochemistry of clavosolide B (2). |
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