High intensity focused ultrasound responsive release behavior of metallo-supramolecular block PPG-PEG copolymer micelles |
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| Affiliation: | 1. International Scientific & Technological Cooperation Base of Industrial Waste Recycling and Advanced Materials, School of Materials Science & Engineering, North Minzu University, Yinchuan 750021, China;2. State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China |
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| Abstract: | An amphiphilic metallo-supramolecular poly(propylene glycol)-block-poly(ethylene glycol) block copolymer containing a bis(2,2′:6′,2″-terpyridine) ruthenium (II) complex as a supramolecular connection between the two constituting blocks was used to prepare stable aqueous micelles which displayed a high intensity focused ultrasound (HIFU) triggered release behavior. By adjusting the HIFU time and intensity, the novel modality of HIFU triggered release allows for fine-tuning of the release kinetics of the encapsulants from the micelles in a remote and controlled way. Nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, and matrix-assisted laser desorption/ionization-time of flight mass spectrometry confirmed that the degradation of the micelles was due to the cleavage of the ether bond connected to the pyridine ring. This well controlled HIFU-copolymer micelle drug delivery system has considerable potential in targeted therapy. |
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| Keywords: | High intensity focused ultrasound Metallo-supramolecular block copolymer Triggered release Drug release Micelle degradation |
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