| α-硫辛酸-(8-生物素酰胺基-3,6-二氧辛基)酰胺的合成 |
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| 引用本文： | 徐常龙,曹小华,陶春元,张康华,谢宝华,张爱东.α-硫辛酸-(8-生物素酰胺基-3,6-二氧辛基)酰胺的合成[J].江西师范大学学报(自然科学版),2008,32(4). |
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| 作者姓名： | 徐常龙 曹小华 陶春元 张康华 谢宝华 张爱东 |
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| 作者单位： | 1. 九江学院化学化工学院,江西,九江,332000
2. 华中师范大学,化学学院,湖北,武汉,430079 |
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| 基金项目： | 国家自然科学基金，江西省自然科学基金，江西省高校教学改革研究项目，九江学院课题 |
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| 摘 要： | 选择α-硫辛酸、长醚链二胺、生物素为主要原料,合成了α-硫辛酸-(8-生物素酰胺基-3,6-二氧辛基)酰胺;并用1HNMR、GC-MS、IR等对中间体及目标产物的分子结构进行了表征.通过改变生物素分子中的侧链部分,可合成不同种类的生物素衍生物,增加了生物素-亲合素/链霉亲合素/中性亲合素自组装膜体系的材料的种类和应用.
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| 关 键 词： | 生物素 α-硫辛酸-(8-生物素酰胺基-3 6-二氧辛基)酰胺 自组装膜 合成 |
Study on Synthesis of Thioctic-(8-Biotinoylamido-3,6-Dioxaoctyl)Amide |
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| XU Chang-long,CAO Xiao-hua,TAO Chun-yuan,ZHANG Kang-hua,XIE Bao-hua,ZHANG Ai-dong.Study on Synthesis of Thioctic-(8-Biotinoylamido-3,6-Dioxaoctyl)Amide[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2008,32(4). |
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| Authors: | XU Chang-long CAO Xiao-hua TAO Chun-yuan ZHANG Kang-hua XIE Bao-hua ZHANG Ai-dong |
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| Institution: | 1.College of Chemistry and Chemical Industry;Jiujiang University;Jiujiang Jiangxi 332000;China;2.College of Chemistry;Center of China Normal University;Wuhan 430079;China |
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| Abstract: | Thioctic-(8-biotinoylamido-3,6-dioxaoctyl)amide were synthesized by thioctic acid,diamine with ether linkage and biotin.The molecular structures of the intermediates and the target compounds were confirmed by 1 H NMR,GC-MS and FT-IR.All kinds of biotinylated molecules can be synthesized by change the side of biotin.Thus applications and kinds of the material of biotin-avidin/streptavidin/neutravidin assembled systems were increased. |
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