| Preparation of 5-Fluorouracil Loaded Polylactide-co-glycolide-co-methoxy Poly（ethylene glycol） （PLGA-mPEG） Nanoparticles via High Speed Shearing |
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| 作者姓名： | LIN Hang ;REN Hui ;WANG Xi-shan ;TANG Qing-chao ;TANG Jun ;WANG Ce |
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| 作者单位： | [1]College of Chemistry, Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, P. R. China; [2]Department of General Surgery, the Second Hospital, Jilin University, Changchun 130023, P. R. China; [3]Department of Abdominal Surgery, the Affiliated Tumor Hospital, Harbin Medical University, Harbin 150081, P. R. China |
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| 基金项目： | Supported by the National Natural Basic Research Program of China(No. 2007CB80800); the Special Foundation of Harbin Technical Innovation for Talental Person(No. 2006RFQXS075) |
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| 摘 要： | 5-Fluorouracil（5-FU） loaded nanoparticles（NPs） were prepared by a high speed shearing double emulsion method with polylactide-co-glycolide-co-methoxy poly（ethylene glycol）（PLGA-mPEG） as loading material. The prepared NPs possess a negative zeta potential and their loading efficiency is about 15%（mass fraction）. The result of in vitro release shows that the release behavior of 5-FU from NPs is coincident with Zero-level release from the second day.
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| 关 键 词： | 纳米颗粒 氟尿嘧啶 聚交酯 乙烯 |
| 收稿时间： | 7 November 2007 |
Preparation of 5-Fluorouracil Loaded Polylactide-co-glycolide-co-methoxy Poly(ethylene glycol) (PLGA-mPEG) Nanoparticles via High Speed Shearing |
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| LIN Hang,;REN Hui,;WANG Xi-shan,;TANG Qing-chao,;TANG Jun,;WANG Ce.Preparation of 5-Fluorouracil Loaded Polylactide-co-glycolide-co-methoxy Poly(ethylene glycol) (PLGA-mPEG) Nanoparticles via High Speed Shearing[J].Chemical Research in Chinese University,2008,24(6):805-808. |
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| Authors: | Hang LIN Hui REN Xi-shan WANG Qing-chao TANG Jun TANG Ce WANG |
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| Institution: | aCollege of Chemistry, Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, P. R. China;bDepartment of General Surgery, the Second Hospital, Jilin University, Changchun 130023, P. R. China;cDepartment of Abdominal Surgery, the Affiliated Tumor Hospital, Harbin Medical University, Harbin 150081, P. R. China |
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| Abstract: | 5-Fluorouracil(5-FU) loaded nanoparticles(NPs) were prepared by a high speed shearing double emulsion method with polylactide-co-glycolide-co-methoxy poly(ethylene glycol)(PLGA-mPEG) as loading material. The prepared NPs possess a negative zeta potential and their loading efficiency is about 15%(mass fraction). The result of in vitro release shows that the release behavior of 5-FU from NPs is coincident with Zero-level release from the second day. |
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| Keywords: | 5-FU PLGA-mPEG Nanoparticle Zeta potential |
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