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Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries |
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| Authors: | Martine Schmitt João X de Araújo-Júnior Said Oumouch Jean-Jacques Bourguignon |
| Institution: | (1) Laboratoire de Pharmacochimie de la Communication Cellulaire (CNRS, UMR 7081), Faculté de Pharmacie, Université Louis Pasteur, 74 route du Rhin, BP24, 67401 Illkirch cedex, France;(2) Curso de Farmácia, Dept° de Medicina Social, Dept° de Química, Universidade Federal de Alagoas, Av. Lourival de Mello Motta, s/n, Tabuleiro dos Martins, 57.072-970 Maceió-AL, Brazil |
| Abstract: | An efficient method for preparation of 4,6 or 5,6 disubstituted 3-aminopyridazines was easily carried out starting from easily available 4-bromo-pyridazine-3,6-dione, and using combination of both amination and Pd(0) cross-coupling reactions under microwave irradiation. |
| Keywords: | 3-aminopyridazines 4-bromo-pyridazine-3 6-dione 3 6-dichloropyridazines amination palladium cross coupling reaction microwave heating combinatorial chemistry |
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