| 豆荚软珊瑚Lobophytum sp. 的次生代谢产物研究 |
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| 引用本文： | 何细新,苏镜娱,曾陇梅,杨小平,梁永钜. 豆荚软珊瑚Lobophytum sp. 的次生代谢产物研究[J]. 化学学报, 2002, 60(2): 334-337 |
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| 作者姓名： | 何细新 苏镜娱 曾陇梅 杨小平 梁永钜 |
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| 作者单位： | 1. 中山大学化学化工学院,广州,510275
2. 中山医科大学肿瘤研究所,广州,510060 |
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| 基金项目： | 国家自然科学基金 (No .2 9932 0 30 )，国家高技术海洋 86 3研究发展计划 (No .2 0 0 1AAA6 2 0 40 3)资助项目 |
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| 摘 要： | 从海南岛三亚海域采集的软珊瑚Labophytumsp.中分离得五个甾醇苷(1)～(5)。通过波谱分析，确定它们的化学结构依次为3'-O-乙酰基-4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(1)，4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(2),4'-O-乙酰基-4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(3),4'-O-乙酰基-4-O-[β-D-吡喃阿拉伯糖苷]-孕甾-20-烯-3β,4α-二醇(4)和4-O-[β-D-吡喃阿拉伯糖苷]-孕甾-20-烯-3β,4α-二醇(5),其中1为新化合物。体外细胞毒性实验表明：化合物(1),(2)和(5)对SKMG-4,Hep-G2和CNE2三种人体癌细胞具有抑制作用。
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| 关 键 词： | 豆荚软珊瑚 细胞毒性试验 甾醇 波谱分析 糖苷 软珊瑚 代谢物 |
| 修稿时间： | 2001-04-12 |
Studies on the secondary metabolite of the soft coral Lobophytum sp. |
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| HE,Xi-Xin SU,Jing-Yu ZENG,Long-Mei. Studies on the secondary metabolite of the soft coral Lobophytum sp.[J]. Acta Chimica Sinica, 2002, 60(2): 334-337 |
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| Authors: | HE Xi-Xin SU Jing-Yu ZENG Long-Mei |
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| Affiliation: | Zhongshan Univ, Sch Chem & Chem Engn.Guangzhou(510275);Sun Yat-sen Univ Med Sci., Cancer Res Inst.Guangzhou(510000) |
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| Abstract: | Five steroidal glycsides (1)～(5) have been isolated from the soft coral Lobophytum sp. , collected from Sanya Bay, Hainan Island. Base on the spectroscopic methods, their structures were determined to be 3'-O-acetyl-4-O-[β-D-xylo- pyranosyl-oxy]-pregn-20-en-3β, 4α-diol (1), 4-O-[β-D-xylo- pyranosyloxy]-pregn-20-en-β, 4α-diol (2), 4'-O- acetyl-4-O- [β-D-xylo-pyranosyl-oxy]-pregn-20-en-3β, 4α-diol(3), 4'-O-acetyl-4-O-[β-D-arabino-pyranosyl-oxy]-pregn-20-en-3β, 4α- diol (4), and 4-O-[β-D-arabinopyranosyl-oxy]-pregn-20-en- 3β, 4α- diol (5). Among them, 1 is a new compound. Bioassay showed that 1, 2 and 5 displayed cytotoxicity against human SKMG-4, Hep-G2 and CNE2 cell lines in vitro. |
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| Keywords: | Lobophytum sp. steroid glycoside cytotoxicity |
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