Synthesis of louisianin C |
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Authors: | Beierle John M Osimboni Ekundayo B Metallinos Costa Zhao Yajun Kelly T Ross |
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Institution: | Department of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA. |
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Abstract: | The synthesis of louisianin C (3), a member of a small family of 3,4,5-trisubstituted pyridyl natural products, is achieved in six steps and 11% overall yield starting from commercially available 3,5-dibromopyridine. The key step is a fluoride-induced desilylation-cyclization to afford carbinol 12. |
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