Discovery and Evaluation of a Functional Ternary Polymer Blend for Bone Repair: Translation from a Microarray to a Clinical Model |
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Authors: | Ferdous Khan James O Smith Janos M Kanczler Rahul S Tare Richard OC Oreffo Mark Bradley |
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Institution: | 1. EaStChem, School of Chemistry, University of Edinburgh, Edinburgh, United Kingdom, EH9 3JJ, UK;2. Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton, SO16 6YD, UK |
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Abstract: | Skeletal tissue regeneration is often required following trauma, where substantial bone or cartilage loss may be encountered and is a significant driver for the development of biomaterials with a defined 3D structural network. Solvent blending is a process that avoids complications associated with conventional thermal or mechanical polymer blending or synthesis, opening up large areas of chemical and physical space, while potentially simplifying regulatory pathways towards in vivo application. Here ternary mixtures of natural and synthetic polymers were solvent blended and evaluated as potential bone tissue engineering matrices for osteoregeneration by the assessment of growth and differentiation of STRO‐1+ skeletal stem cells. Several of the blend materials were found to be excellent supports for human bone marrow‐derived STRO‐1+ skeletal cells and fetal skeletal cells, with the optimized blend exhibiting in vivo osteogenic potential, suggesting that these polymer blends could act as suitable matrices for bioengineering of hard tissues. |
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Keywords: | biomaterials skeletal tissue scaffold skeletal stem cells tissue engineering polymer blends |
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