| 两亲性嵌段共聚物复合胶束在高强聚焦超声下的释放响应行为 |
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| 引用本文： | 王杰,夏和生,赵越.两亲性嵌段共聚物复合胶束在高强聚焦超声下的释放响应行为[J].合成化学,2009,17(3). |
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| 作者姓名： | 王杰 夏和生 赵越 |
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| 作者单位： | 1. 四川大学,高分子研究所,高分子材料工程国家重点实验室,四川,成都,610065
2. Department of Chemistry, University of Sherbrooke, Sherbrooke, Québec, J1K 2R1, Canada |
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| 基金项目： | 教育部新世纪优秀人才支持计划，四川省杰出青年基金 |
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| 摘 要： | 采用共溶剂法制备了聚氧乙烯-b-聚(芘甲基丙烯酸甲酯)两亲性嵌段共聚物胶束(ACM)和由ACM包覆疏水染料尼罗红的复合胶束(ACM-N).采用IR,扫描电镜(SEM),动态光散射仪(DLS)监测ACM-N中尼罗红在高强聚焦超声辐射下的释放响应行为.监测结果表明,超声辐射使共聚物的大部分酯键断裂,由两亲性变为单亲水性,胶束结构被破坏.
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| 关 键 词： | 聚焦超声 嵌段共聚物 胶束 释放响应行为 |
Responsive Release Behavior of Amphiphilic Copolymer Micelles under High Intensity Focused Ultrasound |
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| WANG Jie,Pelletier Maxime,XIA He-sheng,ZHAO Yue.Responsive Release Behavior of Amphiphilic Copolymer Micelles under High Intensity Focused Ultrasound[J].Chinese Journal of Synthetic Chemistry,2009,17(3). |
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| Authors: | WANG Jie Pelletier Maxime XIA He-sheng ZHAO Yue |
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| Institution: | 1. State Key Laboratory of Polymer Materials Engineering;Polymer Research Institute;Sichuan University;Chengdu 610065;China;2. Department of Chemistry;University of Sherbrooke;Sherbrooke;Québec;J1K 2R1;Canada |
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| Abstract: | Poly(ethylene oxide)-b-polymethacrylate bearing pyrene moiety in the side group diblock copolymer micelle(ACM) was prepared by co-solvent method. Nile Red,as a hydrophobic dye,was encapsulated into the hydrophobic inner core of ACM to obtain complex micelles(ACM-N). The release behavior of Nile Red in ACM-N under high intensity focused ultrasound was monitored by IR,SEM and DLS. The results showed that the breaking of ester bond in PPy block transformed the amphiphilic diblock copolymer into hydrophilic,whi... |
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| Keywords: | high intensity focused ultrasound copolymer micelle responsive release behavior |
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