Lactate Mapping with Full Sensitivity by Spin-Filtered NMR Imaging |
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| Affiliation: | 1. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada;2. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada;3. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada |
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| Abstract: | The mechanism of the fourfold signal loss during the cyclic polarization-transfer (CYCLPOT) sequence for lactate filtering is analyzed using the spin-product-operator formalism. Based on the results of the analysis, a new sequence, RECYCLPOT (refocused CYCLPOT), is proposed and experimentally tested for lactate filtering with full sensitivity and specificity. Lactate mapping is performed by spin filtering using the RECYCLPOT sequence prior to imaging by spatial encoding. |
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