Libraries of composite polyfluors built from fluorescent deoxyribosides |
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Authors: | Gao Jianmin Strässler Christoph Tahmassebi Deborah Kool Eric T |
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Institution: | Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA. |
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Abstract: | We report on a new class of water-soluble fluorescent molecules (polyfluors) that are composed of multiple individual fluorophores assembled on a DNA-like backbone. Four fluorophore deoxyribosides were synthesized, and these individual molecules were assembled into oligofluor strings on a DNA synthesizer. A library of 256 tetrafluors was generated by split and pool methods on polystyrene beads. Images of the library under a fluorescence microscope revealed at least 40-50 different hues and intensities. Selected tetrafluors were resynthesized in pure form in solution and displayed properties, such as large Stokes shifts, that individual fluorophores do not have. |
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