Capillary zone electrophoresis determination of oxytetracycline in pig tissue samples at maximum residue limits |
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Authors: | M Hernández F Borrull M Calull |
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Institution: | (1) Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, P. Imperial Tárraco 1, 43005 Tarragona, Spain |
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Abstract: | Summary The determination of the antibiotic oxytetracycline (OTC), in pig tissues was investigated by capillary zone electrophoresis
(CZE) with a prior solid-phase extraction (SPE) using alkyl-bonded silica and polymeric cartridges. The methodology developed
allows determination of OTC in pig kidney, liver and muscle samples with detection limits below maximum residue limit values,
and the procedures to extract OTC and clean-up the matrix are simple and reliable. The limit of detection for OTC was 160,
120 and 85 μg kg−1 for kidney, liver and muscle samples, respectively. The average recoveries from spiked samples (200 μg kg−1 and 1600 μg kg−1) were in excess of 63% with coefficients of variation between 2.0 and 9.8%. This method would be useful for routine monitoring
of oxytetracycline residues in pig tissues. |
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Keywords: | Capillary zone electrophoresis Solid-phase extraction Oxytetracycline Tissue samples |
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