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Characterisation and antiproliferative activity of irinotecan and sulphonatocalixarene inclusion complex |
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| Authors: | Guo-Song Wang Heng-Yi Zhang Dong Li Pu-Yue Wang |
| Affiliation: | 1. State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry , Nankai University , Tianjin, 300071, P.R. China;2. School of Medicine, Nankai University , Tianjin, 300071, P.R. China;3. The College of Life Sciences, Nankai University , Tianjin, 300071, P.R. China |
| Abstract: | The interaction between water-soluble sulphonatocalix[4]arene (SC4A) and irinotecan (CPT-11) was investigated by using UV spectrophotometry. Inclusion complex of SC4A with CPT-11 was confirmed by 1H NMR and DSC analysis. Water solubility study showed that SC4A has remarkable solubilisation on CPT-11 and the complex has good water solubility. The antiproliferative activity of the complex was evaluated. The results showed that the complexation of CPT-11 with SC4A increases the antiproliferative activity of CPT-11. |
| Keywords: | sulphonatocalixarene inclusion complex irinotecan antiproliferative activity supramolecular chemistry |