An Improved Synthesis of Per(6-Deoxyhalo) Cyclodextrins Using N-Halosuccinimides —Triphenylphosphine in Dimethylformamide |
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| Authors: | Kazimierz Chmurski Jacques Defaye |
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| Affiliation: | 1. CNRS (UMR 5063) and Université Joseph Fourier — Grenoble 1, Département de Pharmacochimie Moléculaire/Glucides , BP 138, F-38243, Meylan, France;2. Medical University of Gdańsk, Faculty of Pharmacy , 80-416 Gdańsk ul. Hallera 107, Poland E-mail: chmurski@eniac.farmacja.amg.gda.pl |
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| Abstract: | Abstract Per(6-deoxy-6-halo) cyclodextrins (bromo, chloro or iodo) have been prepared in excellent yield and high selectivity by treatment of the native cyclodextrins with the corresponding N-halosuccinimide and triphenylphosphine in N,N-dimethylformamide. |
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